Tolcapone-d4 (Tolcapone-d4) is a labeled compound that is structurally similar to Tolcapone, but it contains the stable isotope deuterium (D4) in the molecule. Tolcapone-d4 is mainly used as an internal standard compound in scientific research and in pharmacokinetic studies and pharmaceutical analysis.
Tolcapone-d4 preparation method is generally obtained by reacting a deuterated reagent with a specific site of tolcapone by a method of synthetic organic chemistry.
In clinical practice, Tolcapone is a drug for the treatment of Parkinson's disease. It enhances the action of dopamine in the brain by inhibiting the activity of Catechol-O-methyltransferase (COMT) and reducing the degradation of the neurotransmitter dopamine. This can relieve the symptoms of movement disorders in people with Parkinson's disease.
About the safety information of Tolcapone-d4, because it is mainly used in scientific research, the safety of human body has not been studied in detail. However, similar to tolcapone, Tolcapone-d4 may cause some side effects, including nausea, vomiting, abdominal pain, and headaches. When using Tolcapone-d4, the dosage should be strictly controlled according to the experimental needs, and follow the relevant laboratory safety procedures.